Immunology

Opening:

• What are pathogens?

• Open Discussion: What would happen if you didn't have an immune system?

• SCIDS video

Pathogens:

Research a viral, bacterial, and fungal pathogen. Illustrate the pathogen. Tell who it affects, what events/problems it causes, where it is found, what are the causes, risk factors and modes of transmission.

Microscope Time:

• Identify and label types of white blood cells under a microscope.

• Worksheet

Opening

• Immune System by the Ameoba Sisters.

Illustrate White Blood Cell (WBC) Jobs:

• Create a poster, story or comic strip illustrating the roles of natural killer cells and phagocytes.

Opening

• Brainstorm: What happens when you get hurt?

• Video About Inflammation

• Leukocyte rolling

  1. Leukocyte movement video

  2. Moving with Paddles?

Flow Chart of Inflammation:

• Research and create a flow chart with illustrations documenting the symptoms of inflammation and the three stages of response.

Opening:

• Introduction to the three lines of defense of the immune response.

• Innate versus adaptive immunity video.

T-Chart:

• Create a T-chart comparing the difference between the innate versus the adaptive immunity.

Illustrate:

• Create a diagram illustrating the structure and function of the primary and secondary organs of the lymphatic system.

Innate Immune System Mindmap:

• Mindmap Innate Immune System components.

  • Basophil

  • Eosinophil

  • Neutrophil

  • Mast cell

  • Natural Killer Cell

Opening:

• Cytokine diseases include: Crohn's, ulcerative colitus, psoriasis, rheumatoid arthritis, Asthma, multiple sclerosis, Alzheimer disease.

• Read: Article cytokines and diseases.

Cytokines Mindmap:

• Create a mind map illustrating the types of cytokines involved in adaptive immunity.

• Read: Article about different types of cytokines.

Opening:

• Introduction to Antigen-Presenting Cells (APC)

Create a MHC T-Chart:

• Research and create a T-chart comparing major histocompatibility complex (MHC) class I and MHC class II molecules. Be sure to talk about CD8+ (cytotoxic) and CD4+ (helper) T cells.

Antigen Processing Poster:

• Create a poster describing the pathways of antigen processing

Extension:

• Read & Discuss: MHC, scent and attraction.

Opening:

• Create KWL chart about antibodies.

• Antibody introduction - What they are, what they do

Antibody Match:

• Paper Antibody/Antigen match.

• I am a pathogen activity.

Opening:

• What is a clone?

• Clonal Selection Theory video

• Antibody processing video

Clonal Selection Flow Chart:

• Create a flow chart explaining the processes of B cell maturation and clonal selection.

Extension:

• Monoclonal antibody creation in the lab

Antibody Types:

• What are the five classes of antibodies. Make a chart comparing and contrasting the different types.

Opening:

• Antibody diversity is emense!

• How would you create the greatest variety of things most efficiently?

• Immunoglobulin genes introduction.

• Read: Structure and function of Immunoglobulin article.

Immunoglobin Diversity:

• Research Immunoglobulin genes (antibody genes) and class-switch recombination. Create a visual or model explaining how immunoglobulin genes achieve diversity in antibody production.

Responses to Antigens

• What is the difference between and primary and a secondary exposure? Create a compare and contrast chart describing the primary and secondary responses to an antigen. Create a graph showing the levels of IgM and IgG responses during a primary and then a secondary exposure.

Complement System Illustration:

• Research how complement system augments an antibody-mediated immune response, illustrate, diagram, or otherwise explain how the complement system works. Compare and contrast the classical complement systems, the alternative complement system, and the lectin pathway.

Opening:

• Antibodies in Research/Intro to Biochemistry

  • Western Blots

  • Chip Assays

  • ELISA

    • Antigen detection

    • Antibody detection

ELISA Lab:

• ELISA Immuno Explorer Lab.

• Answer: Lab questions.

Opening:

• Cow pox, small pox and milkmaids

Brochure About Antibody Uses:

• Research the various uses of antibodies in the clinic to save lives. Research convalescent plasma, vaccinations/immunizations, and about monoclonal antibodies to treat cancer. Make a brochure explaining how they work, for what diseases they may treat, their efficacy and their side-effects (if any).

Extension:

• Interactive traditional versus mRNA vaccines slides.

Blood Transfusion Timeline:

• Create history of blood transfusion timeline.

Opening:

• ABO blood type.

• Blood agglutination.

Rh Blood Group:

• Create a timeline about the history of the discovery of the Rh factor and its clinical significance.

Read:

• Blood type and cross matching article.

• Blood banking.

Opening:

• Organ transplant - origin and modern ethics.

Research Tissue Transplantation

• Read: 2020: Current Challenges and Resiliency in Organ Transplantation.

• Be the Match attempts to match potential door with patients in need.

• Research the role of cell-mediated immunity as it relates to tissue transplantation. How does organ rejection work? How is it avoided? Be detailed.

Human's vs. Animal's Blood Types:

• Create chart comparing the various blood types of different animals.

T-Cell Brochure

• Create a brochure illustrating the various functions of the different T-cells (helper, cytotoxic, memory). Identify the different ways infected cell can be elimination by T-cells.

Immune System Over a Lifetime:

• Read: Evolution of the immune system in humans from infancy to old age.

• Create a brochure explaining the immune in infancy, childhood, adulthood, and old-age.

Mindmap Comparing Immune Systems:

• Read: Evolution of the immune system.

• Read: Comparative Immune Systems in Animals

• Read: Immune system and immune responses in fish and their role in comparative immunity study: A model for higher organisms.

• Create a mindmap comparing various animals immune systems.